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Ruth L Martin Selected Research

Neoplasms (Cancer)

10/2017Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours.
5/20071,4-Dihydroindeno[1,2-c]pyrazoles with acetylenic side chains as novel and potent multitargeted receptor tyrosine kinase inhibitors with low affinity for the hERG ion channel.
4/2007Discovery of N-(4-(3-amino-1H-indazol-4-yl)phenyl)-N'-(2-fluoro-5-methylphenyl)urea (ABT-869), a 3-aminoindazole-based orally active multitargeted receptor tyrosine kinase inhibitor.

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Ruth L Martin Research Topics

Disease

3Neoplasms (Cancer)
10/2017 - 04/2007
2Long QT Syndrome
07/2007 - 11/2006
2Torsades de Pointes (Torsade de Pointes)
07/2007 - 11/2006
2Edema (Dropsy)
05/2007 - 04/2007
1Prostatic Neoplasms (Prostate Cancer)
10/2017
1Neuroblastoma
09/2007
1Cardiac Sudden Death (Sudden Cardiac Arrest)
07/2007
1Hypotension (Low Blood Pressure)
06/2007
1Breast Neoplasms (Breast Cancer)
05/2007
1Fibrosarcoma
04/2007
1Urinary Incontinence
11/2006
1Seizures (Absence Seizure)
01/2004
1Hypothermia
01/2004
1Ataxia (Dyssynergia)
01/2004
1Cognitive Dysfunction
01/2004

Drug/Important Bio-Agent (IBA)

3Pharmaceutical PreparationsIBA
10/2017 - 11/2006
2Estradiol (Delestrogen)FDA LinkGeneric
05/2007 - 04/2007
1Androgen Receptors (Androgen Receptor)IBA
10/2017
1CREB-Binding ProteinIBA
10/2017
1AndrogensIBA
10/2017
1Histone Acetyltransferases (Histone Acetyltransferase)IBA
10/2017
1Histones (Histone)IBA
10/2017
1Histone Deacetylase InhibitorsIBA
10/2017
1chloramine-T (Clorina)IBA
09/2007
1Methionine (L-Methionine)FDA Link
09/2007
1pyridineIBA
06/2007
1Proto-Oncogene Proteins c-akt (Protein Kinase B)IBA
06/2007
1IndazolesIBA
06/2007
1Phosphotransferases (Kinase)IBA
05/2007
1Sunitinib (Sutent)FDA Link
05/2007
1terodiline (TD 758)IBA
11/2006
1Tolterodine Tartrate (Detrol)FDA Link
11/2006
1Ether (Diethyl Ether)IBA
11/2006
1PotassiumIBA
11/2006
1Nicotinic Receptors (Nicotinic Acetylcholine Receptor)IBA
01/2004
1pozaniclineIBA
01/2004

Therapy/Procedure

1Castration
10/2017